The endothelium is comprised of thousands of endothelial cells that actually form the inner lining of lymph and blood vessels. This thin inner lining has a very important function. That function is to secrete Nitric-Oxide or (NO). Nitric-Oxide is important for maintaining vascular health. Nitric-Oxide is also known to protect the heart, motivate the brain and kill off harmful bacteria.
When Nitric-Oxide levels are inhibited due to damage of the endothelium, endothelial dysfunction occurs. Endothelial dysfunction happens when cells that should remain in the blood begin to leak out of the blood vessels due to damage of the endothelium, and then subsequently leak into surrounding cell tissues.
The Nitric-Oxide that is released from the cells of the endothelium causes athersclerosis and thrombosis to the blood vessels because the blood vessels are no longer protected resulting from the imbalance of nitric-oxide. Other disease occur as a result because Nitric-Oxide is the signaling relaxing factor mechanism for the endothelium cells that maintains the 60,000 miles of blood vessels throughout the body. This means that the endothelium can communicate with vascular tissues throughout the body. Without the proper balance of Nitric-Oxide production as a signaling relaxing factor in the endothelium it becomes dysfunctional. Hence, the nitric-oxide produced is responsible for coagulation, oxidation,vascular tone and inflammation within the endothelial cells and subsequent blood vessels. This is because the nitric-oxide regulates and maintains the normal body functions and helps rid the body of disease by signaling throughout the endothelium for proper function.
Endothelial dysfunction is associated with many diseases such as: ALS,atherosclerosis, diabetes, glaucoma, heart disease, hypertension, lupus, MS, parkinson's, sleep apnea, stroke, thrombosis, and renal failure.
In the situation of spontaneous coronary artery dissection or (SCAD) which occurs when a separation develops between the layers of the wall of one of the blood vessels(artery) that provides blood to the heart. This causes the damaged vessel to be filled with blood and block blood flow through the artery. Endothelial cells become dysfunctional because nitric-oxide is unable to function properly in the endothelium since the levels become imbalanced due to endothelial damage and without proper signaling from the nitric-oxide due to low levels, the remaining 60,000 miles of vessels are at risk including vessels in the heart.
My questions is: because of factors such as stress which produces the hormone cortisol; acute infections such as: pneumonia, sepsis, staph, lymes disease; and air pollutants, carbon monoxide and other issues; can these factors cause endothelial cell damage enough to weaken blood vessels and cause them split or tear as in the instance of (SCAD)? If so, then supplements such as L-Arginine, curcumin and vitamin C may be good to take(they can keep the office running properly) but you should consult with a herbalist or physician before doing so.